A National Institutes of Health-funded study published Jan. 19 in the New England Journal of Medicine claimed to find that cross-sex hormones caused improvements in psychosocial functioning for transgender and nonbinary adolescents. However, two participants committed suicide while another 11 developed suicidal ideation, according to the study. Among 315 transgender and nonbinary participants aged 12 to 20, two committed suicide during the two-year study, and biological males saw no improvements in depression, anxiety or life satisfaction, researchers reported. The researchers claimed to find a causal relationship between cross-sex hormones and psychosocial improvements, but the research was based on an observational study rather than a randomized trial, and it lacked a control group, meaning it wasn’t possible to determine whether the hormones or something else had caused any improvements in patients’ mental health.
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