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Religion Title: New Chromosome Research Undermines Human-Chimp Similarity Claims New Chromosome Research Undermines Human-Chimp Similarity Claims A recent high-profile article in the journal Nature released the results of a study with implications that shocked the scientific community because they contradict long-held claims of human-chimp DNA similarity.1 A previous Acts & Facts article showed that much of the research surrounding the often touted claims of 98 percent (or higher) DNA similarity between chimps and humans has been based on flawed and biased research.2 The problem is that the similarity has been uncertain because no one has performed an unbiased and comprehensive DNA similarity study until now. And the results are not good news for the story of human evolution. One of the main deficiencies with the original chimpanzee genome sequence published in 20053 was that it was a draft sequence and only represented a 3.6-fold random coverage of the 21 chimpanzee autosomes, and a 1.8-fold redundancy of the X and Y sex chromosomes. In a draft coverage, very small fragments of the genome are sequenced in millions of individual reactions using high-throughput robotics equipment. This produces individual sequence fragments of about 500 to 1,200 bases in length. Based on overlapping reads, these individual sequences are assembled into contiguous clusters of sequence called sequencing contigs. In the case of a chimpanzee, an organism with a genome size of about 3 billion bases, a 3.6-fold coverage means that approximately 10.8 billion bases of DNA were sequenced (3.6 x 3.0). The result is a data set consisting of thousands of random sequencing contigs, or islands of contiguous sequence that need to be oriented and placed in position on their respective chromosomes. In the 2005 chimpanzee genome project and resulting Nature journal publication, the sequence contigs4 were not assembled and oriented based on a map of the chimpanzee genome, but rather on a map of the human genome. Given the fact that the chimpanzee genome is at least 10 percent larger5 overall than the human genome, this method of assembly was not only biased toward an evolutionary presupposition of human-chimp similarity, but was also inherently flawed. The title of the recent journal article accurately sums up the research findings: "Chimpanzee and Human Y Chromosomes are Remarkably Divergent in Structure and Gene Content." Before getting into the details of their results, it is important to understand that for the first time, the chimpanzee DNA sequence for a chromosome was assembled and oriented based on a Y chromosome map/framework built for chimpanzee and not human. As a result, the chimpanzee DNA sequence could then be more accurately compared to the human Y chromosome because it was standing on its own merit. The Y chromosome is found only in males and contains many genes that specify male features, as well as genetic and regulatory information that is expressed throughout the whole body. Because of the recent outcome comparing the chimp and human Y chromosomes in a more objective assessment, it is possible that major discrepancies will be revealed among the other chromosomes that are claimed to be so similar. From a large-scale perspective, the human and chimp Y chromosomes were constructed entirely differently. On the human Y chromosome, there were found four major categories of DNA sequence that occupy specific regions. One can think of this in terms of geography. Just as a continent like Europe is divided into countries because of different people groups, so are chromosomes with different categories of DNA sequence. Not only were the locations of DNA categories completely different between human and chimp, but so were their proportions. One sequence class, or category containing DNA with a characteristic sequence, within the chimpanzee Y chromosome had less than 10 percent similarity with the same class in the human Y chromosome, and vice versa. Another large class shared only half the similarities of the other species, and vice versa. One differed by as much as 3.3-fold (330 percent), and a class specific to human "has no counterpart in the chimpanzee MSY [male-specific Y chromosome]."1 As far as looking at specific genes, the chimp and human Y chromosomes had a dramatic difference in gene content of 53 percent. In other words, the chimp was lacking approximately half of the genes found on a human Y chromosome. Because genes occur in families or similarity categories, the researchers also sought to determine if there was any difference in actual gene categories. They found a shocking 33 percent difference. The human Y chromosome contains a third more gene categories--entirely different classes of genes--compared to chimps. Under evolutionary assumptions of long and gradual genetic changes, the Y chromosome structures, layouts, genes, and other sequences should be much the same in both species, given the relatively short--according to the evolutionary timeline--six-million-year time span since chimpanzees and humans supposedly diverged from a common ancestor. Instead, the differences between the Y chromosomes are marked. R. Scott Hawley, a genetics researcher at the Stowers Institute in Kansas City who wasn't involved in the research, told the Associated Press, "That result is astounding."6 Because virtually every structural aspect of the human and chimp Y chromosomes was different, it was hard to arrive at an overall similarity estimate between the two. The researchers did postulate an overall 70 percent similarity, which did not take into account size differences or structural arrangement differences. This was done by concluding that only 70 percent of the chimp sequence could be aligned with the human sequence--not taking into account differences within the alignments. In other words, 70 percent was a conservative estimate, especially when considering that 50 percent of the human genes were missing from the chimp, and that the regions that did have some similarity were located in completely different patterns. When all aspects of non-similarity--sequence categories, genes, gene families, and gene position--are taken into account, it is safe to say that the overall similarity was lower than 70 percent. The Nature article expressed the discrepancy between this data and standard evolutionary interpretations in a rather intriguing way: "Indeed, at 6 million years of separation, the difference in MSY gene content in chimpanzee and human is more comparable to the difference in autosomal gene content in chicken and human, at 310 million years of separation."1 So, the human Y chromosome looks just as different from a chimp as the other human chromosomes do from a chicken. And to explain where all these differences between humans and chimps came from, believers in big-picture evolution are forced to invent stories of major chromosomal rearrangements and rapid generation of vast amounts of many new genes, along with accompanying regulatory DNA. However, since each respective Y chromosome appears fully integrated and interdependently stable with its host organism, the most logical inference from the Y chromosome data is that humans and chimpanzees were each specially created as distinct creatures. References * Dr. Tomkins is Research Associate and Mr. Thomas is Science Writer at the Institute for Creation Research. Cite this article: Tomkins, J. and B. Thomas. 2010. New Chromosome Research Undermines Human-Chimp Similarity Claims. Acts & Facts. 39 (4): 4-5.
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#2. To: WhiteSands, A K A Stone, War, Skip Intro (#0)
Well, well, well... Let's get back to my assertion on another thread that humans and apes did NOT evolve from a common ancestor. More generally that there isn't any evidence that one species can evolve into an entirely new species (where "species" is defined as a breading boundary.) There is no evidence anywhere of parents having children which are incapable of breeding with the parents (but are capable of breeding with each other). NONE. Yes, dogs, wolves and coyotes are part of the same family and their differences are the result of mutation, so they can still breed with each other. Humans and chimps cannot breed with each other. We are not part of the same family and there is no evidence that we evolved from a common ancestor. "Evolution" is a belief system, not a science, just like man-made global warming.
There you go claiming biology isn't science again.
Of course that is not what I said at all. In fact, this article which disproves that chimps and humans are close relatives is completely based on biology. There is a huge difference between modern biology and 150 year old ideology. I will side with modern science, which discovers new evidence all of the time that invalidates old theories and beliefs.
So true. When I was in school , prior to DNA testing, Neanderthal man was in the line of ape to man. If we evolve , there should be millions of mssing links found from every species that exists. There should be hundreds of thousands of "missing links" for each species. None for any species have been found.
And where would you find all of them?
All over the place if they existed. But they don't. You guys have been waiting over a hundred and whatever years for some proof, any proof. But it never comes.
Of course, you and whitey have looked everywhere on earth for these remains, right? What makes you "think" that they'd all get preserved, since preservation of remains is incredibly rare? Of course, to understand the problem you'd have to have an elementary understanding of earth processes. I guess that since the earth is only six thousand years old, you don't think there's any point in that, right?
#18. To: Skip Intro (#17)
Yeah, like when global floods happen. They even say there was a sea right here in Ohio. Lots of sea creature fossils. More proof of a global flood and that the Bible is true and reliable.
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